Polyphyllin I
POLYPHYLLIN D
CAS: 50773-41-6
Molecular Formula: C44H70O16
Polyphyllin I - Names and Identifiers
| Name | POLYPHYLLIN D |
| Synonyms | Polyphyllin Polyphyllin I Polyphyllin A Polyphyllin C POLYPHYLLIN D Paris saponin Pa Paridis saponin I |
| CAS | 50773-41-6 |
Polyphyllin I - Physico-chemical Properties
| Molecular Formula | C44H70O16 |
| Molar Mass | 855.027 |
| Density | 1.40 |
| Melting Point | >245°C (dec.) |
| Specific Rotation(α) | -115°(C=0.373, Ethanol) |
| Solubility | Insoluble in water, petroleum ether, benzene, soluble in methanol, ethanol. |
| Appearance | Form Solid, color White |
| pKa | 12?+-.0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| MDL | MFCD12407435 |
| Physical and Chemical Properties | Chemical properties white crystalline powder, easily soluble in methanol and water, derived from heavy buildings. |
| Use | Uses for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-inflammatory, anti-tumor, anti-virus, lower cholesterol, lower blood pressure and other effects. |
Polyphyllin I - Risk and Safety
| HS Code | 29389090 |
Polyphyllin I - Reference
| Reference Show more | 1. Liu Jia, Yang Yali, Zhang Peng, et al. Analysis of the content of saponins in different parts of 4 kinds of Paris polyphylla [J]. Chinese Journal of Experimental formulology, 2016, Vol. 22, 16, pages 44-48. 2. Wang Haiming, et al. Determination of four saponins in Rhizoma Paridis by HPLC [J]. Journal of Dalian Minzu University, 2018, 20(001):17-20. 3. Ye Feifei, Xu Haobo, Wang Chunxia, et al. Simultaneous determination and cluster analysis of four saponins from Paris polyphylla [J]. Chinese patent medicine 2016 38(11):2413-2413. 4. Qian Lei, Chen Yang. Optimization of the extraction process of the effective components from the flower of Paris polyphylla [J]. Journal of Huaihua University 2019(5). 5. Liu Jia, Zhang Peng, Song Fa-Jun, etc. Analysis of the content of four kinds of saponins in the ground part of Paris polyphylla [J]. Shi Zhen, National Medicine, 2015, 026(005):1233-1235. 6. Dong Fanhe, shoujinhao, Chen Yufeng, Zhang Huiting, Lou Yunwei, Yang Zijian, Zhang Yun. Experimental study of polyphylla saponin I attenuating tricalcium phosphate wear particle-induced osteoblast injury by inhibiting autophagy [J]. Chinese herbal medicine, 2020,51(09):2501-2508. 7. Liu Xuewen, Yang Rui, Zhao Hongyan, si yuan, Liu Ying, King. Inhibition of proliferation and induction of apoptosis of glioma U251 cells by direct targeting STAT3 with Paridis saponin Ⅰ [J]. Journal of tumors, 2020,40(03):163-171. 8. To Yu Chen, Yang Rui, Zhou Tong, si yuan, Liu Xuewen, Liu Ying. Study on the mechanism of the inhibition of prostate cancer metastasis by downregulation of CIP2A/PP2A/ERK signaling pathway [J]. Journal of Hubei University of Medicine, 2019,38(03):201-208. 9. Liu Xiaofen, Yang Chengzi, Huang Zehao, etc. Characteristics of Rhizoma Paridis and content analysis of four saponins [J]. Fujian Traditional Chinese Medicine, 2014, 045(001):53-56. 10. Liu Xiaofen, Huang Xiaozhi, Wang Heshan. Quality Evaluation and Analysis of cultivated Paridis in Fujian province [J]. Fujian Traditional Chinese Medicine, 2012, 43(005):53-55. 11. Wang Shibao, Cai Yanni, Jia Huimei et al. Determination of seven steroidal saponins in Rhizoma Paridis from different sources by HPLC [J]. Northwest Pharmaceutical Journal, 2017, 32(002):133-138. 12. Wang Shibao, Su Ying, Li Huining et al. Optimization of reflux extraction of steroidal saponins from Rhizoma Paridis by response surface methodology [J]. Shaanxi Agricultural Sciences 2019 065(001):46-52. 13. Yu Qing-qing, Li Zheng-yuan, du BO-Yu. Effects of polyphyllin Ⅰ On proliferation of hepatocellular carcinoma cell lines Huh7 and HepG2 [J]. Modern medicine and health, 2020,36(22):3551-3554. 14. Yu Qingqing, Fan Xu, Zhu Min, Yu Xueyan, du Puyu. Preliminary Study on anti-hepatoma effect of Rhizoma Paridis saponin Ⅰ [J]. Chinese Journal of Immunology, 2021,37(01):57-60 65. 15. Peng Peng, Jin Xin, Shen Jie, King, Yu Chen, Liu Ying. Mechanism of polyphylla saponin Ⅰ inducing autophagy in non-small cell lung cancer by activating AMPK signaling pathway [J]. Journal of Hubei University of Medicine, 2021,40(01):1-6 15 113. 16. Liu, Feng, et al. "Comparative analysis of proteinic and metabolic profiles of different species of Paris." Journal of proteomics 200 (2019): 11-27.https://doi.org/10.1016/j.jprot.2019.02.003 17. Liu, Feng, et al. "Comparative analysis of proteomic and metabolomic profiles of different species of Paris." Journal of proteomics 200 (2019): 11-27.https://doi.org/10.1016/j.jprot.2019.02.003 18. [IF=4.072] Yan Yin et al."A cytochrome P450 monooxygenase responsible for the C- 22 hydroxylation step in the Paris polyphylla steroidal saponin biosynthesis pathway."Phytochemistry. 2018 Dec;156:116 19. [IF=4.044] Feng Liu et al."Comparative analysis of proteomic and metabolomic profiles of different species of Paris."J Proteomics. 2019 May;200:11 20. [IF=3.571] Xuewen Liu et al."Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer."Int J Oncol. 2018 Sep;53(3):1279-1288 21. [IF=2.439] Yunfei Zhang et al."Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis."J Pharmacol Sci. 2018 Jul;137:305 22. [IF=5.645] Bo Li et al."Organ-specific transcriptome sequencing and mining of genes involved in polyphyllin biosynthesis in Paris polyphylla."Ind Crop Prod. 2020 Nov;156:112775 23. [IF=4.242] Shun Zhou et al."Anthelmintic efficacy of 35 herbal medicines against a monogenean parasite, Gyrodactylus kobayashii, infecting goldfish (Carassius auratus)."Aquaculture. 2020 May;521:734992 24. [IF=3] Ming-Ming LIU et al."Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer."Chin J Nat Medicines. 2021 Apr;19:255 25. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 26. [IF=4.412] Feng Su et al."Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves."MOLECULES. 2022 Jan;27(9):2724 |
Polyphyllin I - Uses and synthesis methods
biological activity
Polyphyllin I is a small molecule monomer extracted from Parisian tea tree for the treatment of infectious diseases and cancer. Polyphyllin I inhibited U251 cell proliferation and induced apoptosis. Polyphyllin I is an activator of the JNK signaling pathway with potential anti-glioma effects.
Target
JNK signaling
PDK1/Akt/mTOR signaling
Last Update：2024-04-10 22:29:15
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View History
Polyphyllin I
DEOXYGUANOSINE 5'-TRIPHOSPHATE, [ALPHA-32P] TETRA-TRIETHYLAMMONIUM SALT
1-溴-4-(二氟甲氧基)苯
2-[(4-CHLOROPHENYL)SULFANYL]-N-(4-ISOPROPYLPHENYL)ACETAMIDE
N-[(2-乙酰氧)乙基][4-[(2-氯-4-硝基苯基)偶氮]-N-甲基苯基]氨基]丙腈
(R)-3-氨基-3-(苯并[D][1,3]二氧杂环戊烯-5-基)丙酸甲酯盐酸盐
5 -氰基-1H -吡唑-4-羧酸乙酯
[2H6]-地尔硫卓[干冰运输]
TIN(II) CHLORIDE DIHYDRATE FOR ANALYSIS EMSURE ACS,ISO,REAG. PH EUR
1-(3-二甲基氨丙基)-3-乙基碳酰亚胺
DEOXYGUANOSINE 5'-TRIPHOSPHATE, [ALPHA-32P] TETRA-TRIETHYLAMMONIUM SALT
1-溴-4-(二氟甲氧基)苯
2-[(4-CHLOROPHENYL)SULFANYL]-N-(4-ISOPROPYLPHENYL)ACETAMIDE
N-[(2-乙酰氧)乙基][4-[(2-氯-4-硝基苯基)偶氮]-N-甲基苯基]氨基]丙腈
(R)-3-氨基-3-(苯并[D][1,3]二氧杂环戊烯-5-基)丙酸甲酯盐酸盐
5 -氰基-1H -吡唑-4-羧酸乙酯
[2H6]-地尔硫卓[干冰运输]
TIN(II) CHLORIDE DIHYDRATE FOR ANALYSIS EMSURE ACS,ISO,REAG. PH EUR
1-(3-二甲基氨丙基)-3-乙基碳酰亚胺